Periodicidad semestral: flujo continuo.
ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)
INTRODUCTION: Lymphatic vascular malformations (LM), also known as “Lymphangiomas”, are congenital anomalies of unknown etiology. The spectrum of injury varies from
simple to complex, affecting continuous sites with degrees of obstruction or compression
of vital organs.
OBJECTIVES: To determine the effectiveness of different treatments in patients with lymphatic
malformations.
MATERIALS AND METHODS:
RESULTS: An observational retrospective descriptive cohort study was performed, without intervention, evaluating: anthropometric data, clinical evaluation of initiation of treatment, type of treatment, clinical outcome and complications, of patients
from the Carlos Andrade Marín Specialty Hospital.
RESULTS: 53 pediatric patients were obtained, with 1:1 distribution in both genders, after classification of subtype, sclerosing treatment (bleomycin or polidocanol) or surgery was administered for a period between 1 to 48 months. Risk factors were associated, previous
surgery was related (p<0.005) with higher rates of complications. 52 patients showed 98.1% effectiveness of the treatment during these evaluated periods.
CONCLUSIONS: Prior surgery was a risk factor affecting treatment response and the number of complications. The most commonly used treatment was bleomycin injection, as it is less invasive than surgery and more accessible than polidocanol, with better resolution rates.
1. Kulungowski AM, Patel M. Lymphatic malformations. Semin Pediatr Surg. 2020;29(5):150971. DOI: 10.1016/j.sempedsurg.2020.150971. Available from:
https://pubmed.ncbi.nlm.nih.gov/33069296/
2. Rockson SG. Progress in the Approach to Lymphatic Vascular Malformation. Lymphat Res Biol. 2019;17(5):495. DOI: 10.1089/lrb.2019.29071.sr. Available from:
https://pubmed.ncbi.nlm.nih.gov/31618140/
3. Kulungowski, A. M., & Patel, M. (2020). Lymphatic malformations.
Seminars in pediatric surgery, 2020: 29(5), 150971. DOI: https://doi.org/10.1016/j.sempedsurg.2020.150971. Available from:
https://www.sciencedirect.com/science/article/abs/pii/S1055858620300913
4. Mohnasky, M., Brondon, J., Lee, S. Y., & Kim, K. R. (2023). Sociodemographic characteristics of pediatric patients with vascular malformations: Results of a single site study. Frontiers in pediatrics, 11, 1078611.
https://doi.org/10.3389/fped.2023.1078611
5. White, C. L., Olivieri, B., Restrepo, R., McKeon, B., Karakas, S. P., & Lee, E. Y. Low-Flow Vascular Malformation Pitfalls: From Clinical Examination to Practical Imaging Evaluation--Part 1, Lymphatic
Malformation Mimickers. AJR. American journal of roentgenology, 2016: 206(5), 940–951. DOI: https://doi.org/10.2214/AJR.15.15793.
Available from:
https://ajronline.org/doi/10.2214/AJR.15.15793
6. Tian, R., Liang, Y., Zhang, W., Wang, J., Shan, Y., Gao, H., Xie, C., Li, J., Xu, M., & Gu, S. Effectiveness of sirolimus in the treatment of complex lymphatic malformations: Single center report of 56
cases. Journal of pediatric surgery, 2020: 55(11), 2454–2458. DOI: https://doi.org/10.1016/j.jpedsurg.2019.12.021. Available from:
https://pubmed.ncbi.nlm.nih.gov/32044101/
7. Poget, M., Fresa, M., El Ezzi, O., Saliou, G., Doan, M. T., & de Buys Roessingh, A. (2022). Lymphatic malformations in children: retrospective review of surgical and interventional management.
Pediatric surgery international, 39(1), 36. DOI: https://doi.org/10.1007/s00383-022-05320-x. Available from:
https://pmc.ncbi.nlm.nih.gov/articles/PMC9722885/
8. Sun, J., Wang, C., Li, J., Song, D., & Guo, L. (2023). The efficacy of bleomycin sclerotherapy in the treatment of lymphatic malformations: a review and meta-analysis. Brazilian journal of otorhinolaryngology, 89(4), 101285. DOI: https://doi.org/10.1016/j.
bjorl.2023.101285. Available from:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10344707/
9. De Corso, E., Cina, A., Salonna, G., Di Cintio, G., Gaudino, S., Panfili, M., Colosimo, C., & Paludetti, G. (2022). Sclerotherapy with polidocanol microfoam in head and neck venous and lymphatic malformations. Acta otorhinolaryngologica Italica: organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale, 42(2), 116–125. DOI: https://doi.org/10.14639/0392-100X-N1310. Available from:
https://pubmed.ncbi.nlm.nih.gov/34297013/
10. Siki, F. O., Sarikaya, M., Gunduz, M., Sekmenli, T., Koksal, Y., & Ciftci, I. (2023). Efficiency and clinical results of bleomycin injection in the treatment of lymphatic malformations. Nigerian journal of clinical practice, 26(8), 1165–1170. DOI: https://doi.org/10.4103/njcp.njcp_99_23. Available from:
https://pubmed.ncbi.nlm.nih.gov/37635612/
11. Castillo, S. D., Baselga, E., & Graupera, M. (2019). PIK3CA mutations in vascular malformations. Current opinion in hematology, 26(3), 170–178. https://doi.org/10.1097/MOH.0000000000000496. Available from:
https://pubmed.ncbi.nlm.nih.gov/30855339/
12. Bonilla-Velez, J., Moore, B. P., Cleves, M. A., Buckmiller, L., & Richter, G. T. (2020). Surgical resection of macrocystic lymphatic malformations of the head and neck: Short and long-term outcomes. International journal of pediatric otorhinolaryngology, 134,110013. DOI: https:// doi.org/10.1016/j.ijporl.2020.110013. Available from:
https://www.sciencedirect.com/science/article/abs/pii/S0165587620301567
13. Rodríguez J, Cáceres F, Vargas P. Manejo del linfangioma con infiltración de OK-432 Cir Pediatr. 2012;25(4):201-204. Available from:
https://www.secipe.org/coldata/upload/revista/2012_25-4_201-204.pdf
14. Gálvez Y, Medina M, Cáceres F. Evaluación del tratamiento de linfangiomas con bleomicina en población pediátrica de 0 a 18 años. CAMbios rev. méd ; 20(2): 53-59, 30 Diciembre 2021. DOI: https://doi.org/10.36015/cambios.v20.n2.2021.353. Available from:
https://revistahcam.iess.gob.ec/index.php/cambios/article/view/353/495
15. Fernandez-Flores, A., Cassarino, D., & Colmenero, I. (2023). Vascular Malformations: A Histopathologic and Conceptual Appraisal. Actas dermo-sifiliograficas, 114(3), 213–228. DOI: https://doi.org/10.1016/j.ad.2022.10.035. Available from:
https://www.sciencedirect.com/science/article/pii/S0001731022009012
16. Moreno-Alfonso, J. C., Triana, P., Miguel Ferrero, M., Díaz González, M., & López Gutiérrez, J. C. (2024). Risk factors for sequelae after surgery for lymphatic malformations in children. Journal of vascular surgery. Venous and lymphatic disorders, 12(2), 101730. DOI: https://doi.org/10.1016/j.jvsv.2023.101730. Available from:
https://www.jvsvenous.org/article/S2213-333X(23)00446-8/fulltext
17. Petkova, M., Kraft, M., Stritt, S., Martinez-Corral, I., Ortsäter, H., Vanlandewijck, M., Jakic, B., Baselga, E., Castillo, S. D., Graupera, M., Betsholtz, C., & Mäkinen, T. Immune-interacting
lymphatic endothelial subtype at capillary terminals drives lymphatic
malformation. The Journal of experimental medicine, 2023: 220(4), e20220741. https://doi.org/10.1084/jem.20220741. Available from:
18. Yamaki, T., Sasaki, Y., Hasegawa, Y., Osada, A., Konoeda, H., Hamahata, A., Nozaki, M., & Sakurai, H. (2017). Percutaneous ultrasound-guided sclerotherapy with polidocanol microfoam for lymphatic malformations. Journal of vascular surgery. Venous and lymphatic disorders, 5(5),
707–714. DOI: https://doi.org/10.1016/j.jvsv.2017.03.017. Available from: https://pubmed.ncbi.nlm.nih.gov/28818226/
19. Petkova, M., Ferby, I., & Mäkinen, T. (2024). Lymphatic malformations:
mechanistic insights and evolving therapeutic frontiers. The Journal of clinical investigation, 2024: 134(6), e172844. DOI: https://doi.org/10.1172/JCI172844. Available from:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10940090/
20. Putra J, Al-Ibraheemi A. Advances in vascular anomalies: refining classification in the molecular era. Histopathology. 2025 Jun;86(7):1032-1043. DOI: 10.1111/his.15374. Epub 2024 Dec 4. PMID: 39628347. Available from:
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