
Periodicidad semestral: flujo continuo.
ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)
INTRODUCTION. Alzheimer’s disease is the leading cause of dementia and produces multiple
cognitive disorders such as the involvement of executive functions. These patients present with
dysexecutive symptoms and impaired frontal release reflexes, although it is unknown whether
they are affected depending on the severity of the dementia. OBJECTIVE. To determine if there is a relationship between the Dissecutive Symptoms and the Frontal Release Reflexes in patients with Alzheimer’s disease. MATERIALS AND METHODS. A descriptive, retrospective study was carried out; 23 patients with Alzheimer’s dementia from the State Reference Center for Care for People with Alzheimer’s Disease were analyzed during the 2013-2014 period. The data were obtained through the dissertation questionnaire, and analyzed using the X2 test and the Mann-Whitney U test. RESULTS. The ages of the participants ranged from 55 to 90 years. The average of scores according to the executive questionnaire showed a value of 21,69. In the planning, significant differences were observed between patients with mild and moderate Alzheimer’s disease (p = 0.020); as well as between the mild and moderately severe phase (p = 0.014). In social consciousness it was similar between the mild and moderate stages (p = 0.036). CONCLUSION. Frontal release reflexes and dissecting symptoms were affected, but no relationship between them and the severity of Alzheimer’s disease was evident. The hypothesis was refuted that, to a greater degree of severity, greater disejecutiva involvement and frontal
release reflexes.
Chayer C, Freedman M. Frontal lobe functions. Curr Neurol Neurosci Rep[Internet]. 2001 [Cited 2019 Jan 10];1(6):547-52. Available from: https://link.springer.com/article/10.1007/s11910-001-0060-4
Stuss DT, & Alexander, MP. Is there a dysexecutive syndrome? Philosophical Transactions of the Royal Society of London Serie B Biological Science[Internet]. 2007 May 29 [Cited 2019 Jan 10]; 362(1481):901-915. DOI: 10.1098/rstb.2007.2096. ISSN:1471-2970. Available from: https://royalsocietypublishing.org/doi/abs/10.1098/rstb.2007.2096
Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, et al. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain[Internet]. 2015 [Citado 2019 Jan 14]; 138(9): 2732-49. DOI: 10.1093/brain/awv191. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26141491
Godefroy O, Martinaud O, Verny M, Mosca C, Lenoir H, Bretault E, et al. The dysexecutive syndrome of Alzheimer's disease: the GREFEX study. J Alzheimers Dis[Internet]. 2014[Cited 2019 Jan 14]; 42: 1203-1208. DOI: 10.3233/JAD-140585. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25024318
Michon A, Deweer B, Pillon B, Agid Y, Dubois B. Relation of anosognosia to frontal lobe dysfunction in Alzheimer's disease J Neurol Neurosurg Psychiatry[Internet]. 1994 Jul[Cited 2019 Jan 15];57(7):805-809. DOI: 10.1136/jnnp.57.7.805. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1073019/
Senanarong V, Cummings JL, Fairbanks L, Mega M, Masterman DM, O'Connor SM, et al. Agitation in Alzheimer's disease is a manifestation of frontal lobe dysfunction. Dement Geriatr Cogn Disord[Internet]. 2004[Cited 2019 Jan 15]; 17: 14-20. DOI: 10.1159/000074080. Available from: https://www.ncbi.nlm.nih.gov/pubmed/14560060
Lee DY, Choo IH, Jhoo JH, Kim KW, Youn JC, Lee DS, et al. Frontal dysfunction underlies depressive syndrome in Alzheimer disease: a FDG-PET study. Am J Geriatr Psychiatry [Internet]. 2006 Jul[Cited 2019 Jan 15];14(7);625-628. DOI: 10.1097/01.JGP.0000214541.79965.2d. Available from: https://www.ncbi.nlm.nih.gov/pubmed/16816017
Nagata T, Shinagawa S, Ochiai Y, Kada H, Kasahara H, Nukariya K. Relationship of frontal lobe dysfunction and aberrant motor behaviors in patients with Alzheimer's disease. Int Psychogeriatr[Internet]. 2010 May [Citado 2019 Jan 20]; 22(3):463-469. DOI: 10.1017/s1041610209991323. Available from: https://www.ncbi.nlm.nih.gov/pubmed/20003629
Koppel J, Sunday S, Goldberg TE, Davies P, Christen E, Greenwald BS, et al. Psychosis in Alzheimer's disease is associated with frontal metabolic impairment and accelerated decline in working memory: findings from the Alzheimer's Disease Neuroimaging Initiative. Am J Geriatr Psychiatry[Internet]. 2014 Jul. [Cited 2019 Jan 20]; 22(7): 698-707. DOI: 10.1016/j.jagp.2012.10.028. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23672944
Peavy GM, Salmon DP, Edland SD, Tam S, Hansen LA, Masliah E, et al. Neuropsychiatric features of frontal lobe dysfunction in autopsy-confirmed patients with lewy bodies and "pure" Alzheimer disease. Am J Geriatr Psychiatry [Internet]. 2013 Mar 13 [Cited 2019 Feb 10]; 21(6): 509-519. DOI: 10.1016/j.jagp.2012.10.022. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664517/
Walker HK, The Suck, Snout, Palmomental, Grasp Reflexes. In: Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. Boston: Butterworths[Internet]. 1990[cited Feb 10];3:363-364. PMID: 21250236. Available from: https://www.ncbi.nlm.nih.gov/books/NBK395/
Gabelle A, Gutierrez LA, Dartigues JF, Ritchie K, Touchon J, Berr C. Palmomental Reflex a Relevant Sign in Early Alzheimer's Disease Diagnosis?. J Alzheimers Dis[Internet]. 2016 [Cited 2019 Feb 10];49(4):1135-41. DOI: 10.3233/JAD-150436. Available from: https://www.ncbi.nlm.nih.gov/pubmed/26639955
Dickerson, BC, Wolk DA, Alzheimer's Disease Neuroimaging Initiative. Dysexecutive versus amnesic phenotypes of very mild Alzheimer's disease are associated with distinct clinical, genetic and cortical thinning characteristics. J Neurol Neurosurg Psychiatry. [Internet]. 2011 Jan [cited Feb 22];82(1): 45-51. DOI: 10.1136/jnnp.2009.199505. Available from: https://www.ncbi.nlm.nih.gov/pubmed/20562467
American Psychiatric Association, A. P. A. Diagnostic and statistical manual of mental disorder. Washington, DC. Fourth edition ed. 2002.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology[Internet]. 1984 Jul[cited Mar 10];34(7):939-944. DOI: 10.1212/wnl.34.7.939. Available from: https://www.ncbi.nlm.nih.gov/pubmed/6610841
Lobo A, Saz P, Marcos G, ZARADEMP G. Examen Cognoscitivo. Madrid. TEA ed. 2002.
López-Pousa S, Llinás J, Amiel J, Vidal C, y Vilalta. CAMDEX: una nueva entrevista psicogeriátrica. Actas luso-españolas, Neurología, Psiquiatría y ciencias afines[Internet]. 1990 [Citado 2019 Mar 10]; 18: 290-295. Disponible en: https://www.researchgate.net/publication/20865515_CAMDEX_a_new_psychogeriatric_interview
Reisberg B, Ferris SH, de Leon MJ, y Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry[Internet]. 1982 Sep [Cited 2019 Mar 10]; 139(9):1136-1139. DOI: 10.1176/ajp.139.9.1136. Available from: https://www.ncbi.nlm.nih.gov/pubmed/7114305
De la Espriella RA, Hernández JF, Espejo LM. Signos de liberación cortical en pacientes con esquizofrenia, trastornos depresivos, trastorno afectivo bipolar, demencia y enfermedad cerebrovascular. Rev Colomb Psiquiat[Internet]. 2013 [Cited Mar 10];42(4):311-319. Disponible en: https://www.redalyc.org/comocitar.oa?id=80629822003
Wilson BA, Alderman N, Burgess PW, Emslie H, y Evans JJ. Behavioural Assessment of the Dysexecutive Syndrome. UK: Thames Balley Test. 1996. Available from: https://www.pearsonclinical.co.uk/Psychology/AdultCognitionNeuropsychologyandLanguage/AdultAttentionExecutiveFunction/BehaviouralAssessmentoftheDysexecutiveSyndrome(BADS)/BehaviouralAssessmentoftheDysexecutiveSyndrome(BADS).aspx
Pedrero EJ, Ruiz JM, Rojo G, Llanero M, Olivar A, Bouso JC, et al. Versión española del Cuestionario Disejecutivo (DEX-Sp): propiedades psicométricas en adictos y población no clínica. Adicciones[Internet]. 2009 [cited 2019 Mar 14]; 21(2): 155-166. Disponible en: http://www.adicciones.es/index.php/adicciones/article/view/243
Pedrero EJ, Ruiz JM, Lozoya P, Llanero M, Rojo G, y Puerta C. Evaluación de los síntomas prefrontales: propiedades psicométricas y datos normativos del cuestionario disejecutivo (DEX) en una muestra de población española. Rev Neurol[Internet]. 2011 Abr 01[cited 2019 Mar 15]; 52(7): 394-404. PMID: 21425108. DOI: https://doi.org/10.33588/rn.5207.2010731. Disponible en: https://www.neurologia.com/articulo/2010731
Meng X, D'Arcy C. Education and Dementia in the Context of the Cognitive Reserve Hypothesis: A Systematic Review with Meta-Analyses and Qualitative Analyses. PLoS One [Internet]. 2012 Jun 04 [cited 2019 Mar 15];7(6):e38268. DOI: 10.1371/journal.pone.0038268. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366926/
Shinagawa Y, Nakaaki S, Hongo J, Murata Y, Sato J, Matsui T, et al. Reliability and validity of the Japanese version of the Dysexecutive Questionnaire (DEX) in Alzheimer’s disease: validation of a behavioral rating scale to assess dysexecutive symptoms in Japanese patients with Alzheimer’s disease. Int J Geriatr Psychiatry[Internet]. 2007 Oct[cited 2019 Mar 16]; 22(10): 951–956. DOI: 10.1002/gps.1768. Available from: https://www.ncbi.nlm.nih.gov/pubmed/17299806
Piquard A, Derouesné C, Meininger V, Lacomblez L. [DEX and executive dysfunction in activities of daily living in Alzheimer's disease and frontotemporal dementia]. Psychol Neuropsychiatr Vieil[Internet]. 2010 Sep[cited 2019 Mar 16]; 8(3): 215-24; quiz 225-7. DOI: 10.1684/pnv.2010.0220. Available from: https://www.ncbi.nlm.nih.gov/pubmed/20739260
Luna P, Seijas R, Tirapu J, Hernáez P, Mata I. Estructura factorial del cuestionario disejecutivo en una muestra de población española con daño cerebral adquirido y quejas de déficit de memoria. Rev Neurol[Internet]. 2012 [cited 2019 May 16]; 55(11): 641-650. Disponible en: https://www.neurologia.com/articulo/2012549
Hogan DB, Ebly EM. Primitive Reflexes and Dementia: Results from the Canadian Study of Health and Aging. Age and Ageing[Internet]. 1995 Sep[cited 2019 May 16]; 24: 375-381. DOI:10.1093/ageing/24.5.375. Available from: https://academic.oup.com/ageing/article-abstract/24/5/375/35702?redirectedFrom=fulltext
Shon JM, Lee DY, Seo EH, Sohn BK, Kim JW, Park SY, et al. Functional neuroanatomical correlates of the executive clock drawing task (CLOX) performance in Alzheimer's disease: a FDG-PET study. Neuroscience[Internet]. 2013 Aug 29 [cited 2019]; 29(246):271-80. DOI: 10.1016/j.neuroscience.2013.05.008. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23673275
Matias JA, Cabrera MN, Fernádez M, Moreno T, Valles M, Porta J, et al. Topography of primitive reflexes in dementia: an F-18 fluorodeoxyglucose positron emission tomography study. Eur J Neurol[Internet]. 2015 Agu [cited 2019 May 20]; 22(8): 1201-7. DOI: 10.1111/ene.12726. Available from: https://www.ncbi.nlm.nih.gov/pubmed/25926068
Molloy D, Clarnette R, Mcllroy W, Guyvant G, Rees L, Lever J. Clinical significance of primitive réflex in Alzheimer Disease. J Am Geriatr Soc[Internet]. 1991 Dec[cited 2019 May 20]; 39(12):1160-1163. DOI: 10.1111/j.1532-5415.1991.tb03567.x. Available from: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1532-5415.1991.tb03567.x
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