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Revista Médica Científica CAMbios

Periodicidad semestral: flujo continuo.

ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)

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Keywords

Thyroid Hormones
Hyperthyroidism
Graves Disease
Antithyroid Agents
Graves Ophthalmopathy
Endocrinology

How to Cite

1.
Management of the patient with hyperthyroidism in the outpatient clinic of the Technical Unit of Endocrinology of the Endocrinology Technical Unit of the Carlos Andrade Marín Hospital. Cambios rev. méd. [Internet]. 2023 Oct. 18 [cited 2025 Nov. 23];22(2):e927. Available from: https://revistahcam.iess.gob.ec/index.php/cambios/article/view/927

Abstract

Hyperthyroidism is a disorder characterized by an excess of thyroid hormones. Iodine deficiency is a key factor in this pathology and in places with iodine deficiency it is associated with thyroid autoimmunity. The prevalence of overt hyperthyroidism varies from 0,2% to 1,3% in iodine-sufficient areas; however, this may vary from country to country due to differences in diagnostic thresholds, assay sensitivity, and selected population. A report from The Third National Health and Nutrition Examination Survey (NHANES III) showed that overt hyperthyroidism occurs in 0,7% of the general population and subclinical hyperthyroidism
in 1,7%1,2. In incidence, the pathology is associated with iodine supplementation, with the highest frequency in areas of deficiencies, due to increased thyroid nodules in the elderly population, having
regions of mountainous areas such as South America, Central Africa and Southwest Asia within this group. A meta-analysis of European studies showed an overall incidence of 50 cases per 100000 person/years1. In Ecuador, according to data from the National Institute of Statistics and Census (INEC) in 2017, 157
cases of hyperthyroidism were reported, of which, Graves’ disease (GD) was the most common cause, followed by toxic multinodular goiter (BMNT) and finally toxic adenoma (TA) with an incidence of 61 %, 24 % and 14 % respectively3. Patients with this pathology have an increased risk of cardiovascular
complications and all-cause mortality, with heart failure being one of the main outcomes, so early diagnosis avoids these events, mainly in the elderly population. The present protocol has been carried out for the correct treatment of this pathology at the Carlos Andrade Marín Specialties Hospital (HECAM).

 

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References

Taylor P, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus J, DAyan C, Okosieme O. Global epidemiology of

hyperthyroidism and hypothyroidism. Nature Reviews Endocrinology. 14, 301–316 (2018).

Available from:

https://www.nature.com/articles/nrendo.2018.18

De Leo S, Lee Sy, Braverman L. Hyperthyroidism. Lancet. 2016;388:906–18. Available from: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)00278- 6/fulltext

Narváez Iñahuazo DF. Descripción y Análisis de Signos y Síntomas en Pacientes con diversos tipos de Hipertiroidismo y Modalidades de Tratamiento practicados en el Servicio de Endocrinología del Hospital Eugenio Espejo entre Enero del 2015 a Diciembre del 2018 Quito: [Tesis]; 2015 – 2018. Disponible en: http://repositorio.puce.edu.ec/handle/22000/17489

Davies TF, Laurberg P, Bahn RS. Hyperthyroid Disorders. Williams Textbook of Endocrinology (pp. 369-415). DOI

1016/B978-0-323-29738-7.00012-5.

ISBN: 978-0- 323-29738-7

Biondi B, Cooper DS. Subclinical Hyperthyroidism. The New England journal of medicine. 379. 1484. DOI: 10.1056/NEJMcp1709318. Available from:

https://www.nejm.org/doi/10.1056/NEJMcp1709318?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed

Zhyzhneuskaya S, Addison C, Tsatlidis V, Weaver JU, Razvi S. The Natural History of Subclinical Hyperthyroidism

in Graves’ Disease: The Rule of Thirds. Thyroid. 2016 Jun. 26(6):765-9. DOI: 1 0 . 1 0 8 9 /thy.2015.0470. Available from:

https://pubmed.ncbi.nlm.nih.gov/27090092/

Davies T, Andersen S, Latif R, Nagayama Y, Barbesino G, Brito M et al. Graves’ disease. Nature Reviews Disease

Primers. 2020 Jul 2; 6 (1). DOI: 10.1038/s41572-020- 0184-y. Available from:

https://pubmed.ncbi.nlm.nih.gov/32616746/

Smith TJ, Hegedus L. Graves’ disease. N Engl J Med. 2016;375:1552–65. DOI: 10.1056/NEJMra1510030.

Available from:

https://www.nejm.org/doi/full/10.1056/nejmra1510030

Freitas, Maria., Albuquerque, Luciano, et all. Diagnóstico e tratamento da doença de Graves. Endocrinologia

Clínica, 7ª Edição 2021. Lucio Vilar.(pp 555- 585) ISBN: 9788527736664. Disponible en:

https://loja.ibcmed.com/produto/endocrinologia-clinica- 7a-edicao-2021-2/

Ross DS, Burch HB, Cooper DS, et al. 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis. Thyroid. 2016 Oct. 26 (10):1343-1421. DOI:

1089/thy.2016.0229. Available from:

https://pubmed.ncbi.nlm.nih.gov/27521067/

Nguyen CT, Sasso EB, Barton L, Mestman JH. Graves’ hyperthyroidism in pregnancy: a clinical review. Clin Diabetes Endocrinol. 2018. Mar 1;4:4. DOI 10.1186/s40842-018- 0054-7. Available from: https://pubmed.ncbi.nlm.nih.gov/29507751/

Alexander EK. et al. 2017 guidelines of the American Thyroid Association for the diagnosis and management

of thyroid disease during pregnancy and the postpartum. Thyroid. 2017 Mar; 27(3):315-389. DOI: 10.1089/

thy.2016.0457. Available from:

https://pubmed.ncbi.nlm.nih.gov/28056690/

Chen Y, Wu X, Wu R, Sun X, Yang B, Wang Y, et al. Changes in profile of lipids and adipokines in patients

with newly diagnosed hypothyroidism and hyperthyroidism. Scientific Reports. 2016; 6. 26174. DOI: 10.1038/srep26174. Available from:

https://www.nature.com/articles/srep26174

Bode H, Ivens B, Bschor T, Schwarzer G, Henssler J, Baethge C. Hyperthyroidism and clinical depression: a systematic review and meta-analysis. Translational Psychiatry. 2022; 12. 362. DOI: 10.1038/s41398-022-02121-7. Available from:

https://www.nature.com/articles/s41398-022-02121-7

Jabbar A, Pingitore A, Pearce S, Zaman A, Lervasi G, Razvi S. Thyroid hormones and cardiovascular disease.

Nature Rviews. Cardiology. 14, 39–55 (2017). DOI: 10.1038/nrcardio.2016.174. Available from :

https://www.nature.com/articles/nrcardio.2016.174

Lakho M, Magsi A, Lakho S, Ali M, Bhanbhro F, Magsi S. Frequency of Hyperthyroidism in Hypokalemic Periodic Paralysis. Pakistan Journal of Medical and Health Sciences. 2022. 16(6): 353-354. DOI 10.53350/pjmhs22166353. Available from:

https://pjmhsonline.com/index.php/pjmhs/article/view/1599

Alqahtani HA, Almagsoodi AA, Alshamrani ND, Almalki TJ, Sumaili AM. Common Electrolyte and Metabolic Abnormalities Among Thyroid Patients. Cureus. 2021 May 30;13(5): e15338. DOI: 10.7759/cureus.15338. eCollection 2021 May. PMID: 34235017 Available from:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8241464/

Tun NN, Beckett G, Zammitt NN, Strachan MW, Seckl JR, Gibb FW. Thyrotropin Receptor Antibody Levels at

Diagnosis and After Thionamide Course Predict Graves’ Disease Relapse. Thyroid. 2016 Aug. 26 (8):1004-1009. DOI: 10.1089/thy.2016.0017. Available from:

https://pubmed.ncbi.nlm.nih.gov/27266892/

Blick C, Nguyen M, Jialal I. Thyrotoxicosis. 2022 Jul 5. Available from: StatPearls. Treasure Island (FL): StatPearls Publishing; 2022 Jan. PMID: 29489233. Available from:

https://www.ncbi.nlm.nih.gov/books/NBK482216/

Kahaly GJ, Bartalena L, Hegedüs L, et al. European Thyroid Association Guideline for the Management

of Graves’ Hyperthyroidism. Eur Thyroid J. 2018 Aug;7(4):167-186. doi: 10.1159/000490384. Epub 2018 Jul

PMID: 30283735; PMCID: PMC6140607. Available from:

https://etj.bioscientifica.com/view/journals/etj/7/4/ETJ490384.xml

Sharma A, Stan MN. Thyrotoxicosis: Diagnosis and Management. Mayo Clin Proc. 2019 Jun;94(6):1048-1064.

Available from:

https://www.mayoclinicproceedings.org/article/S0025-6196(18)30799-7/fulltext

Varadharajan K, Choudhury N. A systematic review of the incidence of thyroid carcinoma in patients undergoing thyroidectomy for thyrotoxicosis. Clin Otolaryngol. 2020. Jul; 45(4): 538-544. Epub 2020 Apr 20. PMID:

Available from:

https://onlinelibrary.wiley.com/doi/10.1111/coa.13527

Roque, Catarina & Sousa Santos, Francisco & Pilli, Tania & Dalmazio, Gilda & Castagna, Maria & Pacini, Furio.

Long-term Effects of Radioiodine in Toxic Multinodular Goiter: Thyroid Volume, Function, and Autoimmunity. The

Journal of Clinical Endocrinology & Metabolism. 2020 Jul 1; 105(7):dgaa214. Available from:

https://academic.oup.com/jcem/article/105/7/e2464/5823841?login=false

 

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