Periodicidad semestral: flujo continuo.
ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)
Cryptococcosis is a fungal disease with global distribution. The cause is generally the reactivation of a latent infection in immunosuppressed patients, months or years after the initial exposure. Cryptococcemia is the clearest manifestation of disseminated disease and is associated with a high percentage of cryptococcal meningitis.
The case of a 25-year-old woman with a recent diagnosis of HIV infection is presented, whose predominant symptoms were chronic diarrhea with significant weight loss and fever, with few neurological manifestations. Due to persistence of fever, blood cultures were performed with the isolation of Cryptococcus and subsequently a lumbar puncture with the same microbiological growth in cerebrospinal fluid. For this reason, a case of disseminated cryptococcosis in an immunosuppressed patient was considered.
Gushiken AC, Saharia KK, Baddley JW. Cryptococcosis. Infect Dis Clin North Am. 2021 Jun;35(2):493–514.
DOI: 10.1016/j.idc.2021.03.012. Available from:
https://pubmed.ncbi.nlm.nih.gov/34016288/
Chen Y, Shi ZW, Strickland AB, Shi M. Cryptococcus neoformans Infection in the Central Nervous System: The
Battle between Host and Pathogen. Journal of Fungi. 2022 Oct 12;8(10):1069. DOI: 10.3390/jof8101069 . Available
from:
https://pubmed.ncbi.nlm.nih.gov/36294634/
Zhao Y, Lin X. Cryptococcus neoformans: Sex, morphogenesis, and virulence. Infection, Genetics and
Evolution. 2021 Apr;89:104731. DOI: 10.1016/j.meegid.2021.104731. Available from:
https://pubmed.ncbi.nlm.nih.gov/33497839/
Strickland AB, Shi M. Mechanisms of fungal dissemination. Cellular and Molecular Life Sciences. 2021
Apr 15;78(7):3219–38. DOI: 10.1007/s00018-020-03736-z . Available from:
https://pubmed.ncbi.nlm.nih.gov/33449153/
Chang CC, Harrison TS, Bicanic TA, Chayakulkeeree M, Sorrell TC, Warris A, et al. Global guideline for the
diagnosis and management of cryptococcosis: an initiative of the ECMM and ISHAM in cooperation with the
ASM. Lancet Infect Dis. 2024 Feb;. DOI: 10.1016/S1473-3099(23)00731-4. Available from:
https://pubmed.ncbi.nlm.nih.gov/38346436/
Organización Panamericana de la Salud. Directrices para el diagnóstico, la prevención y el tratamiento de la criptococosis en adultos, adolescentes y niños con infección por el VIH. Washington, DC: OPS; 2023. Available from:
https://iris.paho.org/handle/10665.2/57718
Firacative C, Lizarazo J, Illnait-Zaragozí MT, Castañeda E. The status of cryptococcosis in Latin America. Mem Inst Oswaldo Cruz. 2018 Apr 5;113(7). DOI: 10.1590/0074-02760170554. Available from:
https://pubmed.ncbi.nlm.nih.gov/29641639/
Leimann BCQ, Koifman RJ. Cryptococcal meningitis in Rio de Janeiro State, Brazil, 1994-2004. Cad Saude Publica. 2008 Nov;24(11):2582–92. Available from:
https://www.scielo.br/j/csp/a/VMLvYnQMKykCMMFnS5z4VJR/?lang=en
Angulo GB, Escorza CA, González NFM. Actualidades y tendencias en la etiología de las meningoencefalitis
causadas por hongos y bacterias (1980-2004). Rev Mex Patol Clin Med Lab. 2005;52(4):240-245. Available from:
https://api.semanticscholar.org/CorpusID:87429685
Escandón P, de Bedout C, Lizarazo J, Agudelo CI, Tobón A, Bello S, et al. Cryptococcosis in Colombia: results
of the national surveillance program for the years 2006-2010. Biomedica. 2012 Sep;32(3):386–98. DOI:
1590/S0120-41572012000300009. Available from:
https://pubmed.ncbi.nlm.nih.gov/23715187/
Akintilo L, Femia A. Disseminated Cryptococcosis. New England Journal of Medicine. 2021 Oct 28;385(18):1699–1699. DOI: 10.1056/NEJMicm2109090. Available from:
https://pubmed.ncbi.nlm.nih.gov/34706174/
Tugume L, Ssebambulidde K, Kasibante J, Ellis J, Wake RM, Gakuru J, et al. Cryptococcal meningitis. Nat Rev Dis Primers. 2023 Nov 9;9(1):62. DOI: 10.1038/s41572-023-00472-z . Available from:
https://pubmed.ncbi.nlm.nih.gov/37945681/
Temfack E, Rim JJB, Spijker R, Loyse A, Chiller T, Pappas PG, et al. Cryptococcal Antigen in Serum and Cerebrospinal Fluid for Detecting Cryptococcal Meningitis in Adults Living With Human Immunodeficiency Virus: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy Studies. Clin Infect Dis Off Publ Infect Dis Soc Am. el 8 de abril de 2021;72(7):1268–78. DOI: doi: 10.1093/cid/ciaa1243. Available from: https://pubmed.ncbi.nlm.nih.gov/32829406/
Govender NP, Meintjes G, Mangena P, Nel J, Potgieter S, Reddy D, et al. Southern African HIV Clinicians Society
guideline for the prevention, diagnosis and management of cryptococcal disease among HIV-infected persons: 2019 update. South Afr J HIV Med. 2019 Nov 8;20(1). DOI: 10.4102/sajhivmed.v20i1.1030. Available from:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7081625/
Jarvis JN, Lawrence DS, Meya DB, Kagimu E, Kasibante J, Mpoza E, et al. Single-Dose Liposomal Amphotericin
B Treatment for Cryptococcal Meningitis. New England Journal of Medicine. 2022 Mar 24;386(12):1109–20. DOI:
1056/NEJMoa2111904. Available from:
https://pubmed.ncbi.nlm.nih.gov/35320642/
Espinel-Ingroff A, Aller AI, Canton E, Castañón-Olivares LR, Chowdhary A, Cordoba S, et al. Cryptococcus neoformans-Cryptococcus gattii species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole. Antimicrob Agents Chemother. 2012 Nov;56(11):5898–906. DOI: 10.1128/AAC.01115-12. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3486550/Dawaher JE, Medina GE, Castro EE
e975
The authors who publish in this journal accept the following conditions:
1. The authors retain the copyright and grant to the CAMbios MEDICAL-SCIENTIFIC JOURNAL HECAM the right of the first publication, with the work registered with the Creative Commons attribution license, which allows third parties to use the published material provided that they mention the authorship of the work and the first publication in this journal.
2. Authors can make other independent and additional contractual agreements for the non-exclusive distribution of the version of the article published in this journal (for example, include it in an institutional repository or publish it in a book) as long as it clearly indicates that the work was published. for the first time in the CAMbios MEDICAL-SCIENTIFIC JOURNAL HECAM.
