Periodicidad semestral: flujo continuo.
ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)
El síndrome de daño de la mucosa relacionada con el estrés (SDMRE), es el término usado para describir, el fenómeno que causa la lesión a nivel del revestimiento del estómago y duodeno, en condiciones de estrés fisiológico. A través de un análisis observacional se reconoce que el uso de profilaxis es amplio y está presente en todos los pacientes tanto en la Unidad de Cuidados Intensivos como fuera de ella, por ello nosotros presentamos una revisión, sobre profilaxis de úlceras de
estrés y cuáles son los pacientes que se benefician de su uso, en el escenario de los cuidados intensivos, basados en la evidencia actual.
Selye H. A (1988). Syndrome produced by diverse nocuous agents. ] Neuropsychiatry ClinNeurosci ;10(2):230—231.
Curling T. (1992)).On acute ulceration of the duodenum in cases ofbum . Medico-Chir Trans. ,25: 260 -281.
- Lucas CE, SugawaC, RiddleJ, et al. (1971). Natural history and surgical dilemma of “stress” gastric bleeding. Arch Surg; 102:266- 273.
- Choung RS, Talley NJ. (2008). Epidemiology and clinical presentation of stress-related peptic damage and chronic peptic ulcer. CurrMol Med; 8:253-257.
- LevR,MolotMD,McNamaraJ,StrempleJF.(1971). “Stress" ulcers follouiing war wounds in Vietnam. A morphologic and histochemical study. Lab Invest; 25(6):491-502.
- Cook DJ, Fuller HD, Guyatt GH, et al (1994). Riskfactors for gastrointestinal bleeding in critically ill patients.Canadian
- Critical Care Triáis Group. N EnglJ Med. ; 330:377-381 Cook DJ, Fuller HD, Griffith LE, Walter SD, et al. (2001).
The attributablemortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients. Crit C are.; 5:368-375.
- Schuster DP, Rowley H, Feinstein S, et al. (1984). Prospective evaluation of the risk of upper gastrointestinal
bleeding after admission to a medical intensive care unit. A m JMed. ; 76:623-630.
- Spirt MI, Stanley S. (2006). Update on stress ulcer prophylaxis in critically ill patients. Crit Care Nurse. ; 26:18-29.
- Mfitz DC.(2005). Preventing the gastrointestinal consequences of stress-related mucosal disease. Curr Med Res Opin.; 21: 11-18.
Martindale R.(2005). Contemporary strategies for the prevention of stress-related mucosal bleeding. A m J HealthSyst Pharm. 2005; 62(10, suppl 2):S11-S17.
- Lewis JD, Shin EJ, Metz DC. (2000). Characterization of gastrointestinal bleeding in severely ill hospitalized patients. Crit Care Med.; 28:46-50.
- Peura DA, Johnson LF. (1985). Cimetidine for prevention and treatment of gastroduodenalmucosal lesions in patients in an intensive care unit. Ann Intem Med; 103:173-177■
Czaja AJ, McAlhany JC, Pruitt BA Jr. (1974). Acute gastroduodenal disease after thermal injury. An endoscopic evaluation of incidence and natural history. N EnglJ Med .4;
:925-929.
- Shuman RB, Schuster DP, Zuckerman GR. (1987). Prophylactic therapy for stress ulcer bleeding: a reappraisal. Ann Intem Med; 106:562-567.
- Mutlu GM, Mutlu EA, (2001). Factor P. GI complications in patients receiving mechanical ventilation. Chest; 119: 1222-1241.
- Fennerty M¡3.(2002). Pathophysiology of the upper gastrointestinal tract in the critically ill patient: rationale for the therapeutic benefits of acid suppression. Crit Care Med; 30:S351-355.
- Alien ME, Kopp BJ, Erstad BL. (2004). Stress ulcer prophylaxis in the postoperative period. Am J Health Syst
Pharm; 61:588-596.
Pimental M, Roberts DE, Bemstein CN, et al. (2009). Clinically significant gastrointestinal bleeding in critically ill patients in an era of prophylaxis. A m J Gastroenterology. ; 95:2801 - 2806.
Laine L, Takeuchi K, Tamawski A . (2008). Gastric mucosal defense and cytoprotection: bench to bedside.
Gastroenterology; 135:41 -60.
- Yasue N, Guth PH.(Í988). Role of exogenous acid and retransfusion in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology; 94:1135 - 1143.
- Shian WM , Sasaki I, Kamiyama Y, et al. (2000). The role of lipid peroxidation on gastric mucosal lesions induced by waterimmersion-restraint stress in rats. Surg Today; 30:49-53.
• Droge W. (2002). Free radicáis in the physiological control of cell function. Physiol Rev; 82:47-95.
- Maride N, Ehrlich K, Gretzer B, et al. (1999). Selective cyclo-oxygenase-2 inhibitors aggravate ischaemia-reperfusion injury in the rat stomach. BrJ Pharmacol; 128:1659-1666.
- Wada K, Kamisaki Y, Ohkura T, et al. (1998). Direct measurement of nitric oxide release in gastric mucosa during ischemia-reperfusion in rats. AmJPhys ; 274:G465—471
- Kobata A , Kotani T, KomatsuY, et al.(2007). Dual action of nitric oxide in the pathogenesis of ischemia/reperfusioninduced mucosal injury in mouse stomach. Digestión;
:188-97.
Michida T, Kawano S, Masuda E, et al. (1997). Endothelin-1 in the gastric mucosa instress ulcers of critically ill patients. Am J Gastroenterol 1997; 92: 1177 - 1181?
- Maynard N , Bihari D, Beale R, et al. (1993). Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAM A; 270: 1203 - 1210.
- Spirt MJ. (2004). Stress-related mucosal disease: riskfactors and prophylactic therapy. Clin Ther; 26:197 -213.
- Ellison R, Perez-Perez G, Welsh C, et al. (1996). Risk factors for upper gastrointestinalbleeding in intensive care unit patients: role of Helicobacter pylori. Federal Hyperimmune Immunoglobulin Therapy Study Group. Crit Care Med; 24:1974- 1981.
- CoursolC, SanzariS(2005). Impact o f stress ulcer prophylaxis algorithm study. Ann Pharmacotherapy,39: 810 - 816.
- Erstad B, CamamoJ, MillerMJ, et al.(1997). Impacting cost and appropriateness of stress ulcer prophylaxis at a university medical center. Crit Care Med; 25:1678 - 1684.
• ASHP,(1999). Therapeutic guidelines on stress ulcer prophylaxis. ASH P commissicm on therapeutics and approved by the ASH P board of directors on 1998. A m J Health Syst Pharm; 56:347 - 379.
- Lam NP, Le PD, Crawford SY, e ta lf1999). National survey of stress ulcer prophylaxis. Crit Care Med; 27:98 - 103.
- Wade E, Rebuck J, Healey M, et al(2002). H2 antagonistinduced thrombocytopenia:is this a real phenomenon?. Intensive Care Med; 28:459 - 465.
Humphries T, Merritt G. Review article (1999). Drug interactions with agents used to treat acid-related diseases. Aliment PharmacolTher; 3: 18- 26.
- Mathot R, Geus W .(l 999). Pharmacodynamic modeling of the acid inhibitory effect of ranitidine in patients in an intensive care unit during prolonged dosing: characterization of tolerance. ClinPharmacolTher ; 66: 1 4 0 - 1511
- Levy M, SeeligC, RobinsonN, et al.(1997). Comparison of omeprazole and ranitidine for stress ulcer prophylaxis. Dig Dis Sci; 42:1255- 1259.
- Phillips J, MetzlerM, Palmieri M, et al. (1996). A prospective study of simplified omeprazole suspensión for the prophylaxis of stress-related mucosal damage. CritCareMed; 24:1793 - 1800.
- Lasky M, M etzlerM, Phillips J.(l 998). A prospective study of omeprazole suspensión to prevent clinically significant gastrointestinal bleeding from stress ulcers in mechanically ventilated trauma patients. J Trauma; 44:527 - 533.
- Andersscm T, Hassan-Alin M, Hasselgren G, and et al. Drug interaction studies with esomeprazole, the (S)-isomer of omeprazole. Clin Pharm; 40:523 - 537.
- Tsai WL, Poon SK, Yu HK, et al. (2000). Nasogastric lansoprazole is effective in sup- pressing gastric acid secretion in critically ill patients. Aliment PharmacolTher; 14:123 -127.
Huber R, Kohl B, Sachs G, et al.(1995). Review article: the continuing development of proton pump inhibitors with particular reference to pantoprazole. Aliment PharmacolTher; 9:363 - 378.
- Somberg L, Morris J, Fantus R, et al. (2008). Intermittent intravenous pantoprazole and continuous cimetídine infusión: effect on gastric pH control in critically ill patients at risk of developing stress-related mucosal disease. ] Trauma; 64:1202 - 1210.
- Cornad S, Gabrielli A, Margolis B, et al. (2005). Randomized, double-blind comparison of immediate-release omeprazole oral suspensión versus intravenous cimetidine for the prevention ofupper gastrointestinal bleeding in critically ill patients. CritCareMed; 33:760 - 765.
- Klebl F, Scholmerich ]. Therapy insighf.Prophylaxis of stressinduced gastro- intestinal bleeding in critically ill patients. NatClinPractGastroenterolHepatol; 4:562 - 570.
Spiess BD.(1994) ■ Hemorrhage, coagulation, and transfusión: a risk-benefit analysis. J CardiothoracVascAnesth; 8 :19-22.
- Cook DJ, Reeve BK, Guyatt GH, et ai. (7996). Stress ulcer prophylaxis in critically ill patients: resolving discordant metaanalyses. JAMA; 275:308 - 314-
- Driks MR, Craven DE, Celli BR, et al. (¡987). Nosocomial pneumonía in intubated patients given sucralfate as compared with antacids or histamine type 2 bbckers. The role of gastric colonization. N EnglJ Med; 317:1376 - 1382.colonization.
- Cook D, Guyatt G, Marshall ], et al. (1998). A comparison of sucralfate and ranitidine for the prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. Canadian CriticalCareTrialsGroup. N Engl J Med; 338:791 - 797.
- Maclaren R, Jarvis C, Fish D. (2001). Use of enteral nutrition for stress ulcer prophy- laxis. Ann Pharmacother; 35:1614- 1623.
Raff T, Germann G, Hartmann B. (1997). The valué of early enteral nutrition in the prophylaxis of stress ulceration in the severely bumed patient. Bums; 23:313 -318.
- Zeitoun A , Zeineddine M, Dimassi H. (2011). Stres ulcer prophylaxis guidelines: Are tehy being implemented in Lebanese health care centers?.World J GastrointestPharmacolTher ; 6: 2 7 - 3 5 .
- Barletta JF, Erstad BL, Fortune JB.(2002). Stress ulcer prophylaxis in trauma patients. CritCare ;6:526 - 530.
- Marik PE, Vasu T, Hirani A , Pachinburavan M.(2010.) Stress ulcer prophylaxis in the new millennium: a
systematic review and meta-analysis Crit Care Med. 2010 N ov;38(ll):2222-8. doi: 1097/CCM.0b013e3181fl7adf.
Review
Chanpura T, Yende S.(2012). Weighing risks and benefits of stress ulcer prophylaxis in critically ill patients. Crit Care 2012 Oct 29;16(5):322. [Epub ahead of print]
Un PC, Chang CH, Hsu PI, Tseng PL, Huang YB (2010). The efficacy and safety of proton pump inhibitors
fs histamine-2 receptor antagonists for stress ulcer bleeding prophylaxis among critical care patients: a meta-analysis. Crit Care Med. 2010 Apr;38(4): 1197-205. doi: 10.1097/ CCM. ObO 13e3181 d69ccf
- Cook DJ, Reeve BK, Guyatt GH, Heyland DK, Griffith LE, Buckingham L, Tryba M.(2010). Stress ulcer prophylaxis in critically ill patients. CritCare. 1996Jan 24-31; 275(4) :308-14.
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