Accidente cerebrovascular isquémico como presentación de neurosífilis meningovascular en pacientes inmunocompetentes

  • Carlos Javier Arequipa Loachamin Medicina Interna
  • Robert Gonzalo Salinas Suikouski Neurosalud Munay, Área de Neurología. El Coca-Ecuador https://orcid.org/0000-0003-2335-9000
Palabras clave: Sífilis, Neurosífilis/tratamiento farmacológico, Accidente Cerebrovascular Isquémico, Líquido Cefalorraquídeo, Penicilina G Procaína, Ceftriaxona

Resumen

INTRODUCCIÓN: La neurosífilis representa la infección del sistema nervioso central por la bacteria Treponema pallidum. Se han descrito complicaciones parenquimatosas y meningovasculares. La enfermedad cerebrovascular isquémica, puede ser la única manifestación de la neurosífilis y puede ocurrir en cualquier fase de la enfermedad. 

Un tratamiento oportuno lleva a una adecuada recuperación y prevención de complicaciones potencialmente mortales e incapacitantes. OBJETIVO: proporcionar una fuente de información actualizada como medio de consulta rápida para personal médico que trata a pacientes con neurosífilis. METODOLOGÍA: Estudio de revisión de 44 artículos y selección de 33 encontradas en la base de datos del motor PUBMED,
Biblioteca Cochrane, portal BVS Ecuador, datos publicados en tesis de la Universidad Central del Ecuador y Pontificia Universidad Católica del Ecuador, cuyas fechas de publicación corresponden en su mayoría a los últimos 5 años, y pocos artículos de años previos que por su relevancia se mantuvieron, el criterio de búsqueda empleado consistió en documentos que contenían datos sobre epidemiología, fisiopatología,
clínica, diagnóstico y tratamiento de enfermedad cerebrovascular isquémica como presentación de neurosífilis. CONCLUSIÓN: La sospecha clínica de neurosífilis en pacientes jóvenes con antecedente epidemiológico orienta a un diagnóstico oportuno y disminuye la mortalidad y complicaciones secundarias a un infarto cerebral. 

Descargas

La descarga de datos todavía no está disponible.

Citas

Abkur TM, Ahmed GS, Alfaki NO, O’Connor M. Neurosyphilis presenting with a stroke-like syndrome. Case Reports [Internet]. 2015 Mar 4;2015(mar04 1):bcr2014206988–bcr2014206988. Available from: https://casereports.bmj.com/lookup/doi/10.1136/bcr-2014-206988

Ropper AH. Neurosyphilis. Longo DL, editor. N Engl J Med [Internet]. 2019 Oct 3;381(14):1358–63. DOI:

1056/NEJMra1906228. Available from:

https://pubmed.ncbi.nlm.nih.gov/31577877/

Ferro JM, Massaro AR, Mas JL. Aetiological diagnosis of ischaemic stroke in young adults. Lancet Neurol [Internet]. 2010; 9(11): 1085–96. Available from:

http://dx.doi.org/10.1016/S1474-4422(10)70251-9. Availablefrom: https://www.thelancet.com/journals/laneur/article/PIIS1474-4422(10)70251-9/fulltext

Cohen D, Shpitalni G, Lifshitz Y, Anani S, Eyal A, Segal G. A Stroke in the Young with Surprising Recovery. Eur J

Case Reports Intern Med [Internet]. 2019 May 24;(Vol 6 No 5): 1. Available from: https://www.ejcrim.com/index.php/EJCRIM/article/view/200

Bologa C, Lionte C, Halit D, Luca C. Case report. Neurosyphilis Masquerading as Stroke in an 84-year-old. J Crit

Care Med [Internet]. 2017 Apr 25;3(2):70–2. Available from:

https://www.sciendo.com/article/10.1515/jccm-2017-0009

Carod Artal FJ. Clinical management of infectious cerebral vasculitides. Expert Rev Neurother [Internet]. 2016 Feb 19;16(2):205–21. Available from:

http://www.tandfonline.com/doi/full/10.1586/14737175.2015.1134321

Ahbeddou N, El Alaoui Taoussi K, Ibrahimi A, Ait Ben Haddou EH, Regragui W, Benomar A, et al. Stroke and

syphilis: A retrospective study of 53 patients. Rev Neurol (Paris) [Internet]. 2018 May 1;174(5):313–8. Available

from:

https://linkinghub.elsevier.com/retrieve/pii/S0035378716303575

Mukku S, Safal S, Pritam R, Nashi S, Nagarathna C, PT S, et al. Neurosyphilis presenting as rapidly progressive

psychosis & dementia – A forgotten entity. Asian J Psychiatr [Internet]. 2019 Feb 1;40:103–6. Available

from:

https://linkinghub.elsevier.com/retrieve/pii/S1876201818308001

Zhang X, Xiao GD, Xu XS, Zhang CY, Liu CF, Cao YJ. A case report and DSA findings of cerebral hemorrhage

caused by syphilitic vasculitis. Neurol Sci [Internet]. 2012 Dec 24;33(6):1411–4. Available from: http://link.springer.com/10.1007/s10072-011-0887-7

Buitrago-Garcia D, Martí-Carvajal AJ, Jimenez A, Conterno LO, Pardo R. Antibiotic therapy for adults with

neurosyphilis. Cochrane Database Syst Rev [Internet]. 2019 May 27;2019(5). Available from:

http://doi.wiley.com/10.1002/14651858.CD011399.pub2

Paca Torres SE, Eusebio S. Prevalencia del Treponema pallidum en el diagnóstico de sífilis en trabajadoras sexuales que acuden al Centro de Salud Centro Histórico usando VDRL como prueba de tamizaje y FTA-ABS como prueba confirmatoria durante el periodo abril – septiembre 2016 [Internet]. [Quito]: Quito: UCE; 2017 [cited 2021 Feb 13]. Available from:

http://www.dspace.uce.edu.ec/handle/25000/9832

Smibert OC, Jenney AWJ, Spelman DW. Management of neurosyphilis: time for a new approach? Intern Med J

[Internet]. 2018 Feb;48(2):204–6. Available from:

http://doi.wiley.com/10.1111/imj.13703

Galindo J, Mier JF, Miranda CA, Rivas JC. Neurosífilis: un problema antiguo que no pierde actualidad. Rev

Colomb Psiquiatr [Internet]. 2017 Oct 1;46:69–76. Available from:

https://linkinghub.elsevier.com/retrieve/pii/S0034745017300586

Marra CM. Neurosyphilis. Contin Lifelong Learn Neurol [Internet]. 2015 Dec;21(6):1714–28. Available

from:

http://journals.lww.com/00132979-201512000-00017

Gonzalez H, Koralnik IJ, Marra CM. Neurosyphilis. 2019; 39 (4); 448–55. DOI: 10.1055/s-0039-1688942.

Available from:

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0039-1688942

Martínez-Methol MS, Ventimiglia FD, Aristimuño AM, de la Colina AN, Bruno JJ, D’Agostino LE. Implementación del algoritmo reverso para el cribado de sífilis en un laboratorio clínico. Rev Chil infectología

[Internet]. 2019 Aug;36(4): 525–30. Available from:

http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182019000400525&lng=en&nrm=iso&tlng=

en

Shi M, Zhou Y, Li Y, Zhu Y, Yang B, Zhong L, et al. Young male with syphilitic cerebral arteritis presents with

signs of acute progressive stroke. Medicine (Baltimore) [Internet]. 2019 Nov; 98(48): e18147. Available from: https://journals.lww.com/10.1097/MD.0000000000018147

Marks M, Lawrence D, Kositz C, Mabey D. Diagnostic performance of PCR assays for the diagnosis of neurosyphilis: a systematic review. Sex Transm Infect [Internet]. 2018 Dec;94(8):585–8. Available from:

https://sti.bmj.com/lookup/doi/10.1136/sextrans-2018-053666

Klein M, Angstwurm K, Esser S, Hahn K, Maschke M, Scheithauer S, et al. German guidelines on the diagnosis

and treatment of neurosyphilis. Neurol Res Pract [Internet]. 2020 Dec 17; 2(1):33. Available from: https://neurolrespract.biomedcentral.com/articles/10.1186/s42466-020-00081-1

Skalnaya A, Fominykh V, Ivashchenko R, Averchenkov D, Grazhdantseva L, Frigo N, et al. Neurosyphilis in the

modern era: Literature review and case series. J Clin Neurosci [Internet]. 2019;69(xxxx):67–73. Available from:

https://doi.org/10.1016/j.jocn.2019.08.033

Levett PN, Fonseca K, Tsang RS, Kadkhoda K, Serhir B, Radons SM, et al. Canadian Public Health Laboratory

Network laboratory Guidelines for the Use of Serological Tests (excluding point-of-care tests) for the Diagnosis of Syphilis in Canada. Can J Infect Dis Med Microbiol [Internet]. 2015;26(supplement a): 6A-12A. Available from:

http://www.hindawi.com/journals/cjidmm/2015/983425/

Chahine LM, Khoriaty RN, Tomford WJ, Hussain MS. The Changing Face of Neurosyphilis. Int J Stroke [Internet]. 2011 Apr 10;6(2):136–43. Available from:

http://journals.sagepub.com/doi/10.1111/j.1747-4949.2010.00568.x

Wengenroth M, Saam T, Hähnel S. Bildgebung zerebraler Vaskulitiden. Radiologe [Internet]. 2016 Jan

;56(1):52–69. Available from:

http://link.springer.com/10.1007/s00117-015-0053-y

Liu LL, Zheng WH, Tong ML, Liu GL, Zhang HL, Fu ZG, et al. Ischemic stroke as a primary symptom of

neurosyphilis among HIV-negative emergency patients. J Neurol Sci [Internet]. 2012;317(1–2):35–9. Available

from:

http://dx.doi.org/10.1016/j.jns.2012.03.003

Ikeda S, Yakushiji Y, Eriguchi M, Fujii Y, Ishitsuka K, Hara H. Neurosyphilis with cerebellar ataxia, personality

change and cognitive decline one year after onset of cerebral infarction. Rinsho Shinkeigaku [Internet].

;58(8):499–504. Available from:

https://www.jstage.jst.go.jp/article/clinicalneurol/58/8/58_cn-001170/_article/-char/ja/

Tuddenham S, Ghanem KG. Neurosyphilis: Knowledge Gaps and Controversies. Sex Transm Dis [Internet]. 2018 Mar;45(3):147–51. Available from:

https://journals.lww.com/00007435-201803000-00003

Tuddenham S, Katz SS, Ghanem KG. Syphilis Laboratory Guidelines: Performance Characteristics of Nontreponemal Antibody Tests. Clin Infect Dis [Internet]. 2020 Jun 24;71(Supplement_1):S21–42. Available from:

https://academic.oup.com/cid/article/71/Supplement_1/S21/5861807

Centers for Disease Control and Prevention. Syphilis (Treponema pallidum). 2018 Case Definition [Internet].

[cited 2021 Feb 12]. CDC. Available from:

https://ndc.services.cdc.gov/case-definitions/syphilis-2018/

Marra CM, Ghanem KG. Syphilis Summit: Difficult Clinical and Patient Management Issues. Sex Transm Dis [Internet]. Centers for Disease Control and Prevention 2018 Journal of the American Sexually Transmitted Diseases Association. Sep 1; 45(9S): S10–12. Available from:

https://journals.lww.com/stdjournal/fulltext/2018/09001/centers_for_disease_control_and_prevention.3.aspx

Accidente cerebrovascular isq

Smibert OC, Abbinga S, Spelman DW, Jenney AWJ. Neurosyphilis: Concordance between cerebrospinal fluid

analysis and subsequent antibiotic strategy for patients undergoing evaluation of a diagnosis of neurosyphilis. Int J Infect Dis [Internet]. 2019; 82:73–6. DOI: https://doi.org/10.1016/j.ijid.2019.03.003. Available from:

https://www.ijidonline.com/article/S1201-9712(19)30130-4/fulltext

Czarnowska-Cubała M, Wiglusz MS, Cubała WJ, Jakuszkowiak-Wojten K, Landowski J, Krysta K. MR findings

in neurosyphilis--a literature review with a focus on a practical approach to neuroimaging. Psychiatr Danub [Internet]. 2013 Sep;25 Suppl 2(SUPPL.2): S153-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/23995166

Shang XJ, He CF, Tang B, Chang XL, Ci C, Sang H. Neuroimaging Features, Follow-Up Analyses, and Comparisons Between Asymptomatic and Symptomatic Neurosyphilis. Dermatol Ther (Heidelb) [Internet]. 2020;10(2):273–83. DOI: https://doi.org/10.1007/s13555-020-00361-3. Available

from:https://link.springer.com/article/10.1007/s13555-020-00361-3

Lee JS, Rhee HY, Yoon SS, Park KC. Neurosyphilis combined with acute anterior thalamic infarction. Neurol Sci

[Internet]. 2017 Nov 13; 38(11): 2061–3. Available from:

https://link.springer.com/article/10.1007/s10072-017-3052-0

Krishnan D, Zaini SSM, Latif KA, Joseph JP. Neurosyphilis presenting as acute ischemic stroke. Clin Med J R Coll Physicians London. 2020; 20(1): 95–7. Available from:

https://pubmed.ncbi.nlm.nih.gov/31941739/

Publicado
2023-12-27
Cómo citar
1.
Arequipa Loachamin C, Salinas Suikouski R. Accidente cerebrovascular isquémico como presentación de neurosífilis meningovascular en pacientes inmunocompetentes. CAMbios-HECAM [Internet]. 27dic.2023 [citado 13sep.2024];22(2):e693. Available from: https://revistahcam.iess.gob.ec/index.php/cambios/article/view/693
Sección
Estudios Originales: Estudios de Revisión