Periodicidad semestral: flujo continuo.
ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)
INTRODUCTION. Sepsis is a state of multisystem dysfunction, which is caused by a dysregulated
host response to infection. Several factors influence the severity, clinical manifestations and
progression of sepsis, such as immunological heterogeneity and dynamic regulation of cell signaling
pathways. The evolution of patients depends on timely treatment, clinical scoring scales
allow to know the estimated mortality. OBJECTIVE. To evaluate mortality in the intensive care
unit; to establish the management and usefulness of applying bundlers to prevent progression
to dysfunction, multiorgan failure and death. METHODOLOGY. Systematic review type research
modality. A bibliographic search was carried out in databases such as Google Scholar, Mendeley,
ScienceDirect, Pubmed, journals such as New England Journal Medicine, Critical Care,
Journal of the American Medical Association, British Medical Journal. We obtained the guidelines
“Surviving Sepsis” update 2021, 3 international guidelines, 10 observational studies, 2 multicenter
studies, 5 randomized trials, 6 systemic reviews, 5 meta-analyses, 1 clinical case report, 4
articles with expert opinions and updates on the subject of sepsis mortality in ICU with a total
of 36 scientific articles. RESULTS. The mortality of sepsis in the intensive care unit, was lower
in the oncological hospital of Guayaquil, followed by Australia, Germany, Quito, France, United
States of America and Vietnam, The highest mortality is observed in patients with connective
tissue diseases. DISCUSSION. The application of bundlers in sepsis is associated with better
survival and shorter days of hospital stay. CONCLUSIONS. The SOFA, APACHE II and SAPS
II scales help to predict mortality efficiently in the early detection and treatment of patients with
acute and high-risk disease.
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