Periodicidad semestral: flujo continuo.
ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)
Introduction: The study seeks to relate vitamin D serum levels in Multiple Sclerosis (MS) patients with disease severity and its progression. Methods: From eighty one MS patients enrolled, fifty were selected to compare to healthy subjects, paired according to age, gender and skin color. Disease severity was assessed using the Kurtzke severity scale, relapses number, solar exposure. Results: The mean vitamin D serum concentration in MS patients (M= 31.9 SD=12.3 ng/ml) was similar to controls’ (M=30.31 SD=8.0 ng/ml; p=0.53). The prevalence of vitamin D insufficiency was 42% (n=22) among cases and 46% (n=23) among controls (p=0.91). The relationship between an optimal vitamin D serum concentration (>40 ng/ml) and a low grade of disability, using a cutoff point in the Kurtzke scale < 3.5, was assessed and a non-significant correlation was found [χ2(1, N=100)= 3.13 p=0.3]. The mean vitamin D level among patients with more than one relapse (M=31.0 ng/ml) was similar to those with less than one relapse (M=32.49, p=0.66). Discusion: There was no difference of vitamin D serum levels between MS patients and the general population. A weak and not significant correlation was found with the degree of disability, measured by the Kurtzke severity scale, and also with the number of relapses.
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