Periodicidad semestral: flujo continuo.
ISSN - Electrónico: 2661-6947 / DOI: 10.36015 • LILACS BIREME (19784); LATINDEX (20666)
Abstract Introduction: Head and neck mucosal melanoma account for 2 to 8% of head and neck melanomas, most of them arising in the nasal cavity or paranasal sinuses. The aim of this report was to review the follow up of patients with sinonasal malignant melanomas (SNMM), treated over a long period of time at a tertiary referral hospital. Methods: Case series of 19 patients surgically treated for SNMM at Social Security Hospital Carlos Andrade Marin and other private clinics from Quito Ecuador. All patients had histologically proven diagnosis; eleven men. Results: The mean age was 64 year-old. The most common symptoms were nasal obstruction and epistaxis. Most tumors were located at the nasal fossa. Extranasal extension occurred in 11 patients. Twelvetumor were at stages III-IV. All patients were surgically treated. Postoperative radiotherapy was given to 7 patients. Local recurrence (11 events) occurred in 9 cases. These events were treated with surgery in 8 patients, eventually associated to radiation therapy (RT) and chemotherapy (CT). Eight out of 9 patients died. Overall survival was 46%. Death was related to extension of the disease and distant metastases. All stage I tumor patients are still alive. Discussion: Most sinonasal melanomas have a poor prognosis, mainly attributed to initial advanced local disease, local recurrence and distant metastasis.
Goldsmith HS. Melanoma: an overview. Cancer J Clin. 1979; 29: 194- 215
Lee PS, Shimizu KT, Tran LM, Juillard G, Calcaterra TC. Mucosal melanoma of the head and neck: The impact of local control on survival. Laryngoscope. 1994; 104: 121- 1263
Mclaughlin CC, Wu XC, Jemal A, Martin HJ, Roche LM, Chen VW. Incidence of noncutaneous melanoma sin the U.S. Cancer. 2005; 103:1000-1007
Marcus DM, Marcus RP, Prabhu RS, Owonikoko TK, Lawson DH, Switchenko J, et al. Rising incidence of mucosal melanoma of the head and neck in the United States. J Skin Cancer. 2012; 2012: 231693
Mckinnon JG, Kokal WA, Neifeld JP, Kay S. Natural history and treatment of mucosal melanoma. J Surg Oncol. 1989; 41: 222- 225
Stern SJ, Guillamondegui OM. Mucosal melanoma of the head and neck. Head Neck. 1991; 13: 22- 27
Kanetaka S, Tsukuda M, Takahashi M, Komatsu M, Niho T, Horiuchi C, Matsuda H. Mucosal melanoma of the head and neck. Exp Ther Med. 2011; 2: 907-910
Dwivedi R, Dwivedi R, Kazi R, Kumar S, Agarwal SP. Mucosal melanoma of nasal cavity and paranasal sinus. J Can Res Ther. 2008; 4: 200- 202
Edge SB, Byrd DR, Compton CC, Fritz AG, Greene FL, Trotti A. AJCC Cancer Staging Handbook. Springer-Verlag. 2010: 93- 101
Michel J, Court A, Fakhry N, Braustein D, Monestier S, Richard MA, et al. Sinonasal mucosal melanomas: the prognostic value of tumor classifications. Head Neck. 2014; 36: 311- 316
Batsakis JG, Suarez P, Naggar AK. Mucosal melanomas of the head and neck. Ann Otol Rhinol Laryngol. 1998; 107: 626- 630
Snow GB, Waal I. Mucosal melanomas of the head and neck. Otolaryngol Clin North Am. 1988; 19: 549- 564
Huang SF, Liao CT, Kan CR, Chen IH. Primary mucosal melanoma of the nasal cavity and paranasal sinuses: 12 years of experience. J Otolaryngol. 2007: 36: 124- 129
Benevenuto D, Andrade BA, Piña AR, León JE, Almeida O, Altemani A. Primary nasal mucosal melanoma in Brazil: clinicopathologic and immunohistochemical study of 12 patients. Ann Diagn Pathol. 2012; 16: 344- 349
Moreno MA, Roberts DB, Kupferman ME, DeMonte F, El-Naggar AK, Williams M, Rosenthal DS, Hanna EY. Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M. D. Anderson Cancer Center. Cancer. 2010; 116: 2215- 2223
Gal TJ, Silver N, Huang B. Demographics and treatment trends in sinonasal mucosal melanoma. Laryngoscope. 2011; 121: 2026- 2033
Wu AJ, Gomez J, Zhung JE, Chan K, Gomez DR, Wolden SL, et al. Radiotherapy after surgical resection for head and neck mucosal melanoma. Am J Clin Oncol. 2010; 33: 281- 285
Christopherson K, Malyapa RS, Werning JW, Morris CG, Kirwan J, Mendenhall WM. Radiation therapy for mucosal melanoma of the head and neck. Am J Clin Oncol. 2015; 38: 87- 89
Mendenhall WM, Amdur RJ, Hinerman RW, Werning JW, Villaret DB, Mendenhall NP. Head and neck mucosal melanoma. Am J Clin Oncol. 2005; 28: 626- 630
Temam S, Mamelle G, Marandas P, Wibault P, Avril MF, Janot F, Julieron M, Schwaab G, Luboinski B. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer. 2005; 103: 313-319
Saigal K, Weed DT, Reis IM, Markoe AM, Wolfson AH, Nguyen-Sperry J. Mucosal melanomas of the head and neck: the role of postoperative radiation therapy. ISRN Oncol. 2012; 2012: 785131
Gilligan D, Slevin NJ. Radical radiotherapy for 28 cases of mucosal melanoma in nasal cavity and sinuses. Br J Radiol. 1991; 64: 1147- 1150
Harwood AR, Cummings BJ. Radiotherapy for mucosal melanomas. Int J Radiat Oncol Biol Phys. 1982; 8: 1121-1126
Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, et al. Radiotherapy plus cetuximab for squamous cell carcinoma of head and neck. N Engl J Med. 2006; 354: 567- 578
Zebary A, Jangard M, Omholt K, Olding RB, Hansson J. KIT, NRAS and BRAF mutations in sinonasal mucosal melanoma: a study of 56 cases. Br J Cancer. 2013; 109: 559- 564
Vandenhende C, Leroy X, Chevalier D, Mortuaire G. Sinonasal mucosal melanoma: retrospective survival study of 25 patients. J Laryngol Otol. 2012; 126: 147 151
Koivunen P, Bäck L, Pukkila M, Laranne J, Kinnunen I, Grénman R, et al. Accuracy of the current TNM classification in predicting survival in patients with sinonasal mucosal melanoma. Laryngoscope. 2012; 122:1734- 1738
Lin J, Li C, Wu G, Zeng Z. Analysis of prognostic factors of primary mucosal melanoma in nasal and oral cavity (article in Chinese). Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012; 26: 49-52
Thariat J, Poissonnet G, Marcy PY, Lattes L, Butori C, Guevara N, et al. Effect of surgical modality and hypofractionated split-course radiotherapy on local control and survival from sinonasal mucosal melanoma. Clin Oncol. 2011; 23: 579- 586
Borst A, Schwipper V. Primary mucosal malignant melanoma of the head and neck. Facial Plast Surg. 2011; 27: 237- 242
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