Minor salivary gland biopsy in the confirmatory diagnosis of Sjögren’s Syndrome and Amyloidosis

Abstract

INTRODUCTION. The work deals with two diseases with the histopathological description of glandular tissue, which will help us identify and corroborate the diagnosis of Sjögren’s Syndrome and Amyloidosis, which, despite being from the same ductal tissue, have very different histopathological characteristics. OBJECTIVE. To demonstrate the use of minor salivary gland biopsy in confirmatory diagnoses of autoimmune pathologies such as: Sjögren’s Syndrome and Amyloidosis, which, being two distinct entities, have the same structure of affectation. CLINICAL CASE. Two histological plates were studied, of a patient with clinical manifestations of Sjögren’s Syndrome and of a patient with Amyloidosis; The biopsy of the minor salivary gland and its respective histopathology were performed, which allowed the two entities to be identified microscopically. DISCUSSION. To address the different etiology, techniques and complementary examinations in the diagnosis of these diseases, and treatment, without neglecting the degree of sensitivity and specificity of each type of biopsy and the debate of which is the ideal and effective method. RESULTS As for the characteristics of minor salivary gland biopsies that followed histopathological pattern of the two diseases, Sjögren’s Syndrome and Amyloidosis, with the modification of glandular tissue and thus demonstrating the usefulness of the technique in the confirmatory diagnosis. CONCLUSION. The use of the technique, minor salivary gland biopsy, was a confirmatory diagnostic method complementary to imaging and clinical laboratory studies